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HRID 1894556作成日：2026年10月25日

N-(2-Methoxyethyl)isopropylamine → 2-{1-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-N-isopropyl-N-(2-methoxy-ethyl)-acetamide

https://huagongshe.com/reaction/1894556

反応式

関与物質

役割名称HCID仕込み量
反応物N-(2-Methoxyethyl)isopropylamineHCID 551575—
反応物{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acidHCID 57670162—
生成物2-{1-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-N-isopropyl-N-(2-methoxy-ethyl)-acetamideHCID 57670080—

反応手順

In a manner analogous to the method described in example 163, {1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acid was coupled with N-isopropyl-N-(2-methoxy-ethyl)amine (TCI-US) to give the title compound. HR-MS (ES, m/z) calculated for C42H55Cl2N5O4 [(M+H)+] 764.3704, observed 764.3703.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08513239B2
出典データセットuspto-grants-2013_08
ORD IDord-5e5e7781c4d44589950b94174308ab0c
出典メモuspto-grants-2013_08