反应详情

In a manner similar to the method described in example 160, (4-amino-piperidin-1-yl)-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-methanone (example 204) was reacted with 3-isocyanato-tetrahydro-thiophene 1,1-dioxide (Chembridge) to give a mixture of diasteremers. The diastereomers were separated by supercritical fluid chromatography (Berger Instrument Multi-Gram II, Whelk-O column, eluting with 40% isopropanol in carbon dioxide) to give the title compound as pre-peak. HR-MS (ES, m/z) calculated for C39H49Cl2N6O5 [(M+H)+] 783.2857, observed 783.2852.

1. customto give
2. additiona mixture of diasteremers
3. customThe diastereomers were separated by supercritical fluid chromatography (Berger Instrument Multi-Gram II, Whelk-O column, eluting with 40% isopropanol in carbon dioxide)