Cyclopentylamine → HCID 57669971, compound

HRID 1894568Notes

Reaction equation

HRID 1894568 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][CH2:38][CH:37]([C:40](O)=[O:41])[CH2:36][CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:43][CH2:44][CH3:45])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH:46]1([NH2:51])[CH2:50][CH2:49][CH2:48][CH2:47]1>>[CH:46]1([NH:51][C:40]([CH:37]2[CH2:38][CH2:39][N:34]([C:32]([N:12]3[C@@:13]([C:25]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=4)([CH3:24])[C@@:14]([C:17]4[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=4)([CH3:16])[N:15]=[C:11]3[C:8]3[CH:9]=[N:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][C:7]=3[O:43][CH2:44][CH3:45])=[O:33])[CH2:35][CH2:36]2)=[O:41])[CH2:50][CH2:49][CH2:48][CH2:47]1

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 57669951HCID 57669951, compound

Product 1

HCID 57669971HCID 57669971, compound

Procedure

In a manner analogous to the method described in example 163, 1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidine-4-carboxylic acid (example 211) was reacted with cyclopentylamine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C40H49Cl2N5O3 [(M+H)+] 718.3285, observed 718.3288.

Sources & evidence

ORD record
ord-b9425419ef034ea5a6010bc4d7aeaa29
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

Loading…