(+)-1-(4-Methylphenyl)ethylamine → 2-{1-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-N-((R)-1-p-tolyl-ethyl)-acetamide

Participants

Role	Name	HCID	Charge
Reactant	(+)-1-(4-Methylphenyl)ethylamine	HCID 7015756	—
Reactant	{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acid	HCID 57670162	—
Product	2-{1-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-N-((R)-1-p-tolyl-ethyl)-acetamide	HCID 57670118	—

Reaction Steps

In a manner analogous to the method described in example 163, {1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acid was reacted with (R)-(+)-1-(4-methylphenyl)ethylamine (Lancaster) to give the title product. LC-MS (ES+) 782 [(M+H)+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513239B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-c18ea4a617bf435cb24059bc54774649
Source note	uspto-grants-2013_08