反应详情

In a 10 ml single-necked round-bottomed flask, 3.1 mg. of ethylmethylformamide is solubilized in 0.25 ml of dry dichloromethane at ambient temperature (colourless solution). Under stirring, 0.0032 ml of phosphorous oxide chloride is added dropwise by syringe. Stirring at ambient temperature is continued for 1.0 hour, whereupon a pink-orange solution is obtained. To this solution, 7.0 mg of 6-(4-chloro-3-trifluoromethyl-phenoxy)-2-methyl-5-trimethylsilanylethynyl-pyridin-3-ylamine dissolved in 0.75 ml of dry dichloromethane is added dropwise by syringe, giving a yellow solution. Stirring is continued at room temperature for 2.5 hours. The mixture is then poured into ice/water (pH=2, water phase). 2 M aqueous NaOH is then added to get a pH of about 11 and stirring is continued for 15 minutes. The mixture is then extracted with two 10 ml portions of diethyl ether. The combined organic phases are then dried over sodium sulfate, filtered and the solvent is removed in vacuo to obtain 6.0 mg of the compound as a yellow oil. RP HPLC: retention time of compound: 1.61 minutes.

1. stirringStirring at ambient temperature
2. customis obtained
3. additionis added dropwise by syringe
4. customgiving a yellow solution
5. stirringStirring
6. waitis continued at room temperature for 2.5 hours
7. customto get a pH of about 11
8. stirringstirring
9. waitis continued for 15 minutes
10. extractionThe mixture is then extracted with two 10 ml portions of diethyl ether
11. dry with materialThe combined organic phases are then dried over sodium sulfate
12. filtrationfiltered
13. customthe solvent is removed in vacuo