Acetic Anhydride → N-(3-fluoro-2-methylphenyl)acetamide

Participants

Reaction Steps

To a solution of 3-fluoro-2-methylaniline (6.00 g, 48 mmol) in dry DCM (100 mL) under nitrogen was added acetic anhydride (7.6 g, 75 mmol). The reaction mixture was stirred at r.t. for 18 h then washed with water (2×50 mL) and NaOH solution (1M, 2×50 mL). The organic layer was dried (MgSO4), filtered and concentrated in vacuo to give the title compound (8.0 g, 100%) as a white solid. δH (CDCl3) 7.56 (1H, s), 7.16 (1H, q, J=7.6 Hz), 6.99 (1H, br s), 6.87 (1H, t, J=8.4 Hz), 2.27 (3H, s), 2.16 (3H, s).

Provenance & Evidence