(4-(Pyridin-2-yloxymethyl)-phenyl)-methanol → 4-((Pyridin-2-yloxy)methyl)benzaldehyde

Participants

Reaction Steps

To a mixture of (4-(pyridin-2-yloxymethyl)-phenyl)-methanol (1.9 g, 8.6 mmol) described in Manufacturing Example 1-1-1 and methylene chloride (30 mL) was added manganese dioxide (15 g, 17 mmol) at room temperature, which was stirred overnight at this temperature. The reaction mixture was filtered through a Celite pad, and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4), to obtain the title compound (770 mg, 42%).

Provenance & Evidence