HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1894675Generated: October 31, 2026
Acetic Acid → (E)-2-((4-(2-Nitrovinyl)benzyl)oxy)pyridine
https://huagongshe.com/reaction/1894675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 4-((Pyridin-2-yloxy)methyl)benzaldehyde | HCID 59255118 | — |
| Solvent | Water | HCID 962 | — |
| Product | (E)-2-((4-(2-Nitrovinyl)benzyl)oxy)pyridine | HCID 58076258 | 74.5% |
Reaction Steps
A mixture of 4-(pyridin-2-yloxymethyl)-benzaldehyde (23.4 g, 110 mmol) described in Manufacturing Example 1-1-2, nitromethane (33.6 g, 550 mmol), ammonium acetate (17.0 g, 220 mmol), and acetic acid (200 mL) was stirred for 1 hour and 45 minutes at 100° C. A small amount of water was added thereto while the reaction solution was stirred under an ice cooling, and the precipitated solids were collected by filtration, so as to obtain title compound (21.0 g, 74.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08513287B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-5519f5a26a594819a4b9480aeda925ba |
|---|
| Source note | uspto-grants-2013_08 |
|---|
