Acetic Acid → HCID 59841576, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate (9.95 g) described in Manufacturing Example 1-3-2, toluene (200 mL), water (120 mL), and acetic acid (16 mL) was stirred for 90 minutes at 73° C. The reaction mixture was cooled to room temperature, ethyl acetate was added to the reaction mixture for extraction, and the organic layer was separated, washed with saturated saline, and dried over anhydrous magnesium sulfate. The solvent was evaporated under a reduced pressure to obtain the title compound (6.82 g).

Provenance & Evidence