Tetrahydrofuran → HCID 25114168, compound

Participants

Reaction Steps

To a tetrahydrofuran solution (90 mL) of tri-n-butylethynyltin (3 g), 2-(4-(2-nitro-ethyl)-benzyloxy)-pyridine (4.9 g) described in Manufacturing Example 1-1-4, and 4-dimethylaminopyridine (116 mg) was added a tetrahydrofuran solution (30 mL) of di-tert-butyl dicarbonate (7.3 g), which was stirred for 15 hours at room temperature. Ethyl acetate and water were added to this mixture. The organic layer was separated, washed with water and saturated saline, dried over anhydrous magnesium sulfate, and filtered. The filtrate was adsorbed to silica gel, and then purified by silica gel column chromatography (heptane:ethyl acetate=4:1) to obtain the title compound (5.3 g).

Provenance & Evidence