反应详情

温度

70 °C

To a methanol 30 mL solution of methyl 4-(2,4,6-trifluorobenzyl)-1H-pyrrole-2-carboxylate (840 mg, 3.1 mmol) was added 5N sodium hydroxide solution (3.1 mL, 16 mmol) and the reaction was stirred in an oil bath at 70° C. overnight. After cooling to rt, pH of the reaction mixture was adjusted to 1.5 to give a gray suspension. The precipitate was collected by suction filtration and dried under vacuum to give the title compound (796 mg).

1. temperatureAfter cooling to rt
2. customto give a gray suspension
3. filtrationThe precipitate was collected by suction filtration
4. customdried under vacuum