HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetohydrazide → tert-Butyl (2-(2-acetylhydrazinyl)-2-oxoethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetohydrazide | HCID 14039 | — |
| Reactant | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl (2-(2-acetylhydrazinyl)-2-oxoethyl)carbamate | HCID 59892150 | — |
Reaction Steps
Under N2 atmosphere, to a dichloromethane 10 mL solution of N-tert-butyloxycarbonyl-glycine (500 mg, 2.85 mmol) was added EEDQ (706 mg, 2.85 mmol). After stirring for 15 min, to it was added acethydrazide (260 mg, 3.51 mmol) and stirring continued at rt overnight. The precipitate was collected by suction filtration to give the title compound as white fluffy solid (496 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513289B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-30927353c6a44b069755079871ad1105 |
| Source note | uspto-grants-2013_08 |