Chloroacetyl chloride → HCID 66646977, compound

Participants

Reaction Steps

To a suspension of 1H-pyrazole-5-carbohydrazide (102 mg, 0.81 mmol) in 7 mL AcOEt was added 1.8 mL of 1M sodium bicarbonate solution and the initial white suspension was stirred for a few minutes until it became completely clear two-phase solution. Upon cooling in an ice-water bath to it was added 0.7 ml AcOEt solution of chloroacetyl chloride (110 mg, 0.97 mmol). After stirring overnight, the reaction mixture was poured into a separatory funnel. The organic layer was separated and the aqueous layer was extracted twice with AcOEt. The combined org layers were dried over anhydrous sodium sulfate, filtered and concentrated to give a white solid (110 mg).

Provenance & Evidence