HCID 59408994, compound → HCID 16743122, compound

Participants

Reaction Steps

(E)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-acrylonitrile (348 mg, 1.7 mmol) and 10% Pd—C (50 mg) in methanol (20 ml) were stirred at room temperature under 1 atmosphere of hydrogen gas for 6 hours. The mixture was filtered through celite washed with methanol and evaporated to dryness to yield 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-propionitrile as an off white solid (310 mg). 400 MHz 1H NMR (CDCl3) δ: 7.32 (d, J=8.4 Hz, 1H), 7.03-6.96 (m, 2H), 6.91 (d, J=6.8 Hz, 1H), 4.11 (t, J=5.6 Hz, 2H), 3.11 (t, J=6.8 Hz, 2H), 2.97 (t, J=6.4 Hz, 2H), 2.66 (t, J=7.2 Hz, 2H), 2.26-2.19 (m, 2H); LCMS: 211 [M+H].

Provenance & Evidence