Hydrochloric Acid → HCID 22556762, compound

Participants

Reaction Steps

A solution of 4,5-dihydro-pyrrolo[3,2,1-hi]indole-2-carboxylic acid ethyl ester (1.117 g) in ethanol (25 ml) and 2M sodium hydroxide (25 ml) was heated to reflux for 1 hour. The mixture was cooled to room temperature and poured into water (300 ml). 1M hydrochloric acid was added until pH1 and the precipitate formed filtered off and washed with water (50 ml). After drying under reduced pressure 4,5-dihydro-pyrrolo[3,2,1-hi]indole-2-carboxylic acid was obtained as a pale yellow powder (884 mg). 400 MHz 1H NMR (DMSO-d6) δ: 12.94 (s, 1H), 7.31 (d, J=7.2 Hz, 1H), 7.01-6.96 (m, 3H), 4.67 (t, J=6.8 Hz, 2H), 3.74 (t, J=6.8 Hz, 2H); LCMS: 188 [M+H].

Provenance & Evidence