Lithium hydroxide, monohydrate → HCID 54759712, compound

Participants

Reaction Conditions

Reaction Steps

A mixture isopropyl 3-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)-benzo[d]thiazol-2-yl)amino)-2,2-dimethylpropanoate (30 mg, 0.065 mmol) in 300 μL dioxane and 300 μL water was treated with lithium hydroxide monohydrate (21.4 mg, 0.57 mmol) and heated at 100° C. for 1 hr. The mixture was concentrated in vacuo and the residue dissolved in about 2 mL of water. The solution was neutralized with 1N HCl then concentrated again in vacuo. The residue was purified by PTLC using two, 1 mm silica plates eluting with 10% MeOH/DCM to give the title compounds. MS (ESI−) m/z 414.98 [M−H]−

Provenance & Evidence