HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1894781Generated: October 25, 2026
(Z)-2-Hydroxy Doxepin → (E)-2-Hydroxy Doxepin
https://huagongshe.com/reaction/1894781
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Z)-2-Hydroxy Doxepin | HCID 67319009 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (E)-2-Hydroxy Doxepin | HCID 59023617 | — |
Reaction Steps
A mixture of (Z)-2-Hydroxy-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg, 8.5×10−6 mol) was dissolved in a mixture of hydrochloric acid (1 mL) and methanol (9 mL) and heated at 140° C. (oil bath) for 4 hr. The product was isolated by means of HPLC and evaporation of solvents.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08513299B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-d7316b5332224b23afe943ea57d90c92 |
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| Source note | uspto-grants-2013_08 |
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