反应详情

温度

85 °C

1 mmol of [(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine and 1 mmol of 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)propanal are introduced into a clean and dry stainless-steel autoclave under an argon atmosphere. The mixture is degassed by three vacuum/argon cycles and 3 mL of distilled and degassed ethanol are added. The solution is stirred at 85° C. for one hour. The iron complex (5 mol %) is added under argon. The autoclave is then placed under hydrogen pressure (5 bars) and the reaction mixture is stirred at 85° C. for 16 hours and then the autoclave is returned to ambient temperature and decompressed.

1. dry with materialdry stainless-steel autoclave under an argon atmosphere
2. customThe mixture is degassed by three vacuum/argon cycles and 3 mL
3. distillationof distilled
4. customdegassed ethanol
5. additionare added
6. additionThe iron complex (5 mol %) is added under argon
7. stirringthe reaction mixture is stirred at 85° C. for 16 hours
8. customis returned to ambient temperature