4,4'-Dimethoxybenzophenone → HCID 86662309, compound

Participants

Reaction Conditions

Reaction Steps

C-(2-Phenylquinolin-7-yl)methylamine (170 mg, 0.73 mmol) and 4,4′-dimethoxybenzophenone (176 mg, 0.73 mmol) were added to a flask under nitrogen. THF (4 mL) and triethylamine (0.30 mL, 2.2 mmol) were then added. The mixture was cooled to −78° C. and titanium tetrachloride (0.080 mL, 0.73 mmol) was added. The reaction mixture was allowed to warm to room temperature. After stirring for 30 minutes the mixture was cooled to −78° C. and triethylamine (2 mL) was added followed by water (3 mL). The mixture was warmed to room temperature and DCM was added. The organic solution was washed with water, dried over sodium sulfate, filtered, and concentrated to dryness in vacuo. The resultant yellow oil was purified by silica gel chromatography (eluted with DCM/heptane 2:1). A light yellow solid (0.247 g, yield 74%) was obtained.

Provenance & Evidence