Benzyl 4-(2-hydroxy-2-methylpropyl)piperidine-1-carboxylate → 2-Methyl-1-(piperidin-4-yl)propan-2-ol

Participants

Reaction Steps

To a solution of 8.5 g of benzyl 4-(2-hydroxy-2-methylpropyl)piperidine-1-carboxylate in 120 mL of methanol was added 500 mg of 10% palladium-carbon, followed by stirring under a hydrogen atmosphere at room temperature for 1 day. Insoluble material was removed by filtration through Celite, and the filtrate was concentrated under reduced pressure to obtain 5.6 g of 2-methyl-1-(piperidin-4-yl)-2-propanol as a white solid.

Provenance & Evidence