HCID 25210765, compound → HCID 59529905, compound

Participants

Reaction Steps

To a solution of 838 mg of 2-methyl-1-{1-[(5-nitro-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol in 15 mL of methanol was added 80 mg of 10% palladium-carbon, followed by stirring under a hydrogen atmosphere at room temperature for 1 day. Insoluble material was removed by filtration through Celite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography [chloroform:methanol=1:0-10:1], and then solidified from hexane-ethyl acetate to obtain 576 mg of 1-{1-[(5-amino-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-methylpropan-2-ol as a pale brown solid.

Provenance & Evidence