Water → HCID 59529934, compound

Participants

Reaction Steps

To a solution of 105 mg of 1-{1-[(5-amino-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-methylpropan-2-ol in 2 mL of dioxane and 2 mL of THF was added 32 μL of acetic anhydride, followed by stirring at room temperature for 2 hours. Water was added to the reaction liquid, followed by extraction with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography [chloroform:methanol=1:0-10:1], and then solidified using ethyl acetate-hexane to obtain 110 mg of N-(2-{[4-(2-hydroxy-2-methylpropyl)piperidin-1-yl]carbonyl}-1H-indol-5-yl) acetamide as a white solid.

Provenance & Evidence