HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoroindole-2-carboxylic acid → HCID 59529931, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoroindole-2-carboxylic acid | HCID 1820 | — |
| Reactant | Carbonate Ion | HCID 19660 | — |
| Reactant | 4-Piperidineethanol | HCID 73953 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | Carbodiimide | HCID 160435 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59529931 | HCID 59529931 | 102.5% |
Reaction Steps
To a solution of 4.1 mg of 4-piperidine ethanol, 5.3 mg of 5-fluoro-1H-indole-2-carboxylic acid, and 4.0 mg of 1-hydroxybenzotriazole in 0.6 mL of DMF was added 100 mg of PS-Carbodiimide (Argonaut Technologies) at room temperature, followed by stirring overnight. To the reaction liquid were added 50 mg of MP-Carbonate (Argonaut Technologies) and 50 mg of PS-Isocyanate (Argonaut Technologies) at room temperature, followed by stirring for 2 hours, and insoluble material was filtered. The filtrate was concentrated under reduced pressure to obtain 8.8 mg of 2-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513422B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-c15474c675f24a34ad15bb0d55ae67ae |
| Source note | uspto-grants-2013_08 |