Thionyl Chloride → HCID 58370342, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (4-Methanesulfonyl-3-methyl-pyridin-2-yl)-methanol (13 g) and chloroform (130 ml) was added thionylchloride (7.5 ml) at 25-30° C. The reaction mixture was then heated to 60-65° C. and maintained at the same temperature for about 30 min. The solvent was distilled off completely under vacuum at 50-55° C. Ethylacetate (52 ml) was added to the crude followed by cooling to 0-10° C. and maintaining the same temperature for about 2 hrs. The compound is then filtered and washed the solid with ethylacetate (10 ml). The compound at 50-55° C. to obtain 12.2 gm of the title compound characterized by 1HNMR data (300 MHz): δ 2.75 (s, 3H), 3.38 (s, 3H), 4.95 (s, 2H), 7.82 (d, 1H), 8.70 (d, 1H) and mass [M]+: 220.06.

Provenance & Evidence