反应详情

Boron trifluoride diethyl etherate (1.82 mL, 14.40 mmol) was slowly added at room temperature to a solution of 6-phenyl-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylic acid methyl ester (1.68 g, 7.20 mmol). A slightly exothermic reaction was observed and after 5 minutes the reaction mixture was quenched by slow addition of saturated aqueous NaHCO3 (50 mL). The resulting mixture was extracted with EtOAc, and the combined organic extracts were washed with water, dried over MgSO4, filtered and evaporated under reduced pressure to give 1.63 g (97% yield) of 3-formyl-3-phenyl-pyrrolidine-1-carboxylic acid methyl ester as a pale yellow oil which was used without further purification.

1. customA slightly exothermic reaction
2. customthe reaction mixture was quenched by slow addition of saturated aqueous NaHCO3 (50 mL)
3. extractionThe resulting mixture was extracted with EtOAc
4. washthe combined organic extracts were washed with water
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated under reduced pressure