HCID 58017223, compound → HCID 58017284, compound

HRID 1895052Notes

Reaction equation

HRID 1895052 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:25][CH2:26][C:27]([CH3:30])([CH3:29])[CH3:28])([CH:13]([C:15]2[C:16]3[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:17]=3[S:18][CH:19]=2)[OH:14])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>O=[Mn]=O>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:25][CH2:26][C:27]([CH3:30])([CH3:29])[CH3:28])([C:13]([C:15]2[C:16]3[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:17]=3[S:18][CH:19]=2)=[O:14])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 58017223HCID 58017223, compound

Product 1

HCID 58017284HCID 58017284, compound

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

3-(3,3-Dimethyl-butyl)-3-(5-fluoro-benzo[b]thiophene-3-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 3-(3,3-dimethyl-butyl)-3-[(5-fluoro-benzo[b]thiophen-3-yl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid tert butyl ester by oxidation with MnO2 using the procedure of step 3 of Example 18.

Sources & evidence

ORD record
ord-1ceb2bd4498b4dcaaf8176cdd826f0d5
Source dataset
uspto-grants-2013_08
Patent number
US08513425B2

Reaction notes

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