HCID 58017222, compound → HCID 58017295, compound

HRID 1895054Notes

Reaction equation

HRID 1895054 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH:20]([C:22]2[S:26][C:25]3[C:27]([F:31])=[CH:28][CH:29]=[CH:30][C:24]=3[CH:23]=2)[OH:21])([CH2:13][CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>O=[Mn]=O>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([C:20]([C:22]2[S:26][C:25]3[C:27]([F:31])=[CH:28][CH:29]=[CH:30][C:24]=3[CH:23]=2)=[O:21])([CH2:13][CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 58017222HCID 58017222, compound

Product 1

HCID 58017295HCID 58017295, compound

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

3-(7-Fluoro-benzo[b]thiophene-2-carbonyl)-3-(tetrahydro-pyran-4-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 3-[(7-fluoro-benzo[b]thiophen-2-yl)-hydroxy-methyl]-3-(tetrahydro-pyran-4-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester by oxidation with MnO2 using the procedure of step 3 of Example 18.

Sources & evidence

ORD record
ord-fae6324fd73141b18f08566957e3183d
Source dataset
uspto-grants-2013_08
Patent number
US08513425B2

Reaction notes

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