Thiophene, 2,3-dichloro- → HCID 58017207, compound

HRID 1895055Notes

Reaction equation

HRID 1895055 reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[Cl:7].[C:8]([O:12][C:13]([N:15]1[CH2:19][CH2:18][C:17]([CH:23]=[O:24])([CH2:20][CH2:21][CH3:22])[CH2:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>>[C:8]([O:12][C:13]([N:15]1[CH2:19][CH2:18][C:17]([CH:23]([C:4]2[S:3][C:2]([Cl:1])=[C:6]([Cl:7])[CH:5]=2)[OH:24])([CH2:20][CH2:21][CH3:22])[CH2:16]1)=[O:14])([CH3:10])([CH3:11])[CH3:9]

Participants

3

Reactant 2

HCID 140207Thiophene, 2,3-dichloro-HCID 58017228HCID 58017228, compound

Product 1

HCID 58017207HCID 58017207, compound

Procedure

3-[(4,5-Dichloro-thiophen-2-yl)-hydroxy-methyl]-3-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 2,3-dichloro-thiophene and 3-formyl-3-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester using the procedure of step 1 of Example 20.

Sources & evidence

ORD record
ord-1338fbdece2e4e41894fb7380f11522d
Source dataset
uspto-grants-2013_08
Patent number
US08513425B2

Reaction notes

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