Ethyl bromopyruvate → HCID 52903990, compound

HRID 1895390Notes

Reaction equation

HRID 1895390 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]([NH2:10])=[S:9])[CH:2]=1.[CH2:11]([O:13][C:14](=[O:19])[C:15](=O)[CH2:16]Br)[CH3:12]>CO>[CH2:11]([O:13][C:14]([C:15]1[N:10]=[C:8]([NH:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[S:9][CH:16]=1)=[O:19])[CH3:12]

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 27605153-Pyridylthiourea

Product 1

HCID 52903990HCID 52903990, compoundYield 79.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester (200 mg) was prepared according to General Procedure B using pyridin-3-yl-thiourea (154 mg) and 3-bromo-2-oxo-propionic acid ethyl ester (200 mg) in methanol (2 mL). The crude product was used in subsequent steps without further purification.

Workup

  1. customThe crude product was used in subsequent steps without further purification

Sources & evidence

ORD record
ord-f22bc225b9594e609f525249a21d1b39
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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