HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 2996058, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | 1-(2-Pyridyl)-2-thiourea | HCID 1490491 | — |
| Reactant | HCID 2996058 | HCID 2996058 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 2996058 | HCID 2996058 | — |
| Product | 232596-44-0 | HCID 18322931 | — |
Reaction Steps
2-(Pyridin-2-ylamino)-thiazole-4-carboxylic acid ethyl ester (195 mg) was prepared according to General Procedure C using pyridin-2-yl-thiourea (154 mg) and 3-bromo-2-oxo-propionic acid ethyl ester (200 mg) in methanol (2 mL). 2-(Pyridin-2-ylamino)-thiazole-4-carboxylic acid (160 mg) was prepared according to General Procedure C using 2-(pyridin-2-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used in a subsequent step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513430B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-9c5370c49ebb4fdd89f9ed8165d2c505 |
| Source note | uspto-grants-2013_08 |