HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromopyruvic Acid → 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromopyruvic Acid | HCID 70684 | — |
| Reactant | Thourea, (4-chlorophenyl)- (9CI) | HCID 735843 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Chloroanilino)-1,3-thiazole-4-carboxylic acid | HCID 2757762 | 94.6% |
Reaction Steps
2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid (240 mg) was prepared according to General Procedure B using (4-chloro-phenyl)-thiourea (186 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513430B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-48f6c1b7cbb24a1e9a7ea9876560e3d4 |
| Source note | uspto-grants-2013_08 |