Bromopyruvic Acid → HCID 80569129, compound

HRID 1895400Notes

Reaction equation

HRID 1895400 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10]([NH2:12])=[S:11])=[CH:3][CH:2]=1.Br[CH2:14][C:15](=O)[C:16]([OH:18])=[O:17]>CO>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10]2[S:11][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[N:12]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 53900107HCID 53900107, compound

Product 1

HCID 80569129HCID 80569129, compoundYield 57.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2-Pyridin-4-yl-ethylamino)-thiazole-4-carboxylic acid (236 mg) was prepared according to General Procedure B using (2-pyridin-4-yl-ethyl)-thiourea (300 mg) and 3-bromo-2-oxo-propionic acid (293 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

Workup

  1. customThe crude product was used in a subsequent step without further purification

Sources & evidence

ORD record
ord-178c9d949d87411a9816e51951b1572f
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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