Hydrochloric Acid → HCID 67425102, compound

Participants

Reaction Conditions

Reaction Steps

1 g of the (6S)-(−)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (I) obtained in Example 3 (96.58% purity by HPLC) was dissolved in 8 mL of ethyl acetate at room temperature. Then, 1.5 mL of 2.5M HCl solution was added in isopropanol. The mixture was cooled for 3 hours at 0-5° C. and a white solid precipitated. The mixture was filtered off to afford 1 g of (6S)-(−)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol hydrochloride (90% yield). The product was analyzed by HPLC and its purity was 98.58%.

Provenance & Evidence