Potassium ethanethioate → HCID 178467360, compound

Participants

Reaction Conditions

Reaction Steps

2-Ethoxy-3-[2′-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide (100 mg, 180 μmol) and potassium thioacetate (31 mg, 15 equiv) were dissolved in MeCN (5 mL) and heated at 90° C. overnight. The solvent was evaporated and the residue partitioned between water (10 mL) and EtOAc (10 mL). The aqueous phase was discarded, the organic layer washed with saturated aqueous NaCl, dried over NaSO4, decanted, and the solvent evaporated. The crude product (80 mg, 70%) was used without further purification. ESMS [M+H]+ calcd for C32H35N7O3S, 597.3. found 598.3.

Provenance & Evidence