HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → (S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (S)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane | HCID 86667891 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Product | (S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride | HCID 50914396 | — |
Reaction Conditions
| Temperature | -78 °C |
|---|
Reaction Steps
tert-Butyl lithium is added to a solution of (S)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane in ether at −78° C. and the mixture stirred at −78° C. for 30 mins. A solution of thionyl chloride in ether is then added, the mixture warmed to room temperature and concentrated under reduced pressure. The residue is dissolved in chloroform, filtered and dried under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513443B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-594f3c5f234c463fb1b5991dc1969e37 |
| Source note | uspto-grants-2013_08 |