Water → Oxybutynin

Participants

Reaction Conditions

Reaction Steps

Oxybutynin chloride (100 gm) was treated with DM water (500 ml) at 25-30° C. and heated to 40-45° C. to observe clear solution. n-Heptane (500 ml) was added to the solution and adjusted the pH of the mass to 10.0-11.0 using 5% sodium hydroxide solution at 20-25° C. Layers obtained were separated and aqueous layer was extracted with heptane. Organic layers were combined and concentrated under vacuum at 40-45° C. to give residue. n-Pentane (250 ml) was added to the residue and stirred under nitrogen atmosphere at 25-30° C. The solid product was filtered and washed with chilled n-pentane. Wet cake was dried at 40-42° C.

Provenance & Evidence