2,2-Dimethyl-5-[2-(2,4,5-trifluoro-phenyl)-acetyl]-[1,3]dioxane-4,6-dione → ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
Reaktionsgleichung
[CH3:1][C:2]1(C)OC(=O)[CH:5]([C:9](=[O:20])[CH2:10][C:11]2[CH:16]=[C:15]([F:17])[C:14]([F:18])=[CH:13][C:12]=2[F:19])[C:4](=[O:21])[O:3]1>C(O)C>[CH2:2]([O:3][C:4](=[O:21])[CH2:5][C:9](=[O:20])[CH2:10][C:11]1[CH:16]=[C:15]([F:17])[C:14]([F:18])=[CH:13][C:12]=1[F:19])[CH3:1]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
2,2-Dimethyl-5-[2-(2,4,5-trifluoro-phenyl)-acetyl]-[1,3]dioxane-4,6-dione 1b (15.72 g, 49.6 mmol) was dissolved in 280 mL of ethanol under stirring, then the reaction mixture was heated to 70° C. in an oil bath overnight. After cooling, the mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound 3-oxo-4-(2,4,5-trifluoro-phenyl)-butyric acid ethyl ester 1c (12 g, yield 88%) as a yellow oil.
Aufarbeitung
- temperatureAfter cooling
- concentrationthe mixture was concentrated under reduced pressure
- customThe resulting residue was purified by silica gel column chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-dd8797eb3a1c4390bcc1de848a8aa8ee
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08513411B2
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