Hydrochloric Acid → (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid (2-methanesulfonyl-ethyl)-amide hydrochloride

HRID 1895590Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1895590
C(OC(=O)[NH:7][C@H:8]([CH2:34][C:35]1[CH:40]=[C:39]([F:41])[C:38]([F:42])=[CH:37][C:36]=1[F:43])[CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]2[C:18]([C:30]([F:33])([F:32])[F:31])=[N:19][C:20]([C:21](=[O:29])[NH:22][CH2:23][CH2:24][S:25]([CH3:28])(=[O:27])=[O:26])=[C:14]2[CH2:13]1)=[O:11])(C)(C)C.[ClH:45]>C(OCC)(=O)C>[ClH:45].[CH3:28][S:25]([CH2:24][CH2:23][NH:22][C:21]([C:20]1[N:19]=[C:18]([C:30]([F:32])([F:31])[F:33])[N:15]2[CH2:16][CH2:17][N:12]([C:10](=[O:11])[CH2:9][C@H:8]([NH2:7])[CH2:34][C:35]3[CH:40]=[C:39]([F:41])[C:38]([F:42])=[CH:37][C:36]=3[F:43])[CH2:13][C:14]=12)=[O:29])(=[O:26])=[O:27]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57518405(R)-[3-[1-(2-methanesulfonyl-ethylcarbamoyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl]-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 44193831(R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid (2-methanesulfonyl-ethyl)-amide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

(R)-[3-[1-(2-Methanesulfonyl-ethylcarbamoyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl]-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 2b (0.06 g, 0.091 mmol) was dissolved in a little ethyl acetate. A solution of 3.1 N hydrochloric acid in 4 mL of ethyl acetate was then added to the solution. The reaction mixture was reacted at room temperature for 4 hours until thin lay chromatography showed the starting material disappeared, and was concentrated under reduced pressure to obtain the title compound (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid (2-methanesulfonyl-ethyl)-amide hydrochloride 2 (60 mg) as a white solid.

Aufarbeitung

  1. customThe reaction mixture was reacted at room temperature for 4 hours
  2. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-780d2b8adb8d40609815eab81bbafb51
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08513411B2

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