反应详情

温度

60 °C

A suspension of palladium on carbon (480 mg, 50 wt % wet, 0.451 mmol) and 6-chloro-4-hydroxy-5-phenylpyridin-2(1H)-one (1000 mg, 4.51 mmol) in EtOH (40 mL) was placed under a hydrogen balloon and stirred at 60° C. After stirring under hydrogen for 30 h, the mixture was filtered while hot through a pad of CELITE® 545 filter aid and rinsed with hot ethanol. The filtrate was concentrated to give 490 mg crude product as a yellow solid. MS (ESI) 188 (M+H).

1. stirringAfter stirring under hydrogen for 30 h
2. filtrationthe mixture was filtered while hot through a pad of CELITE® 545
3. filtrationfilter aid
4. washrinsed with hot ethanol
5. concentrationThe filtrate was concentrated