HRID1895829

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID439309

3,6,8-Trihydroxy-3,4-dihydronaphthalen-1(2H)-one

C10H10O4

HCID439428

1,3,8-Trihydroxynaphthalene

C10H8O3

结构：CC(C)(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O

HCID644066

Malonyl coenzyme A

C24H38N7O19P3S

PRODUCTS

生成物

HCID440202

1,3,6,8-Tetrahydroxynaphthalene

C10H8O4

PROCEDURE

实验过程

Biosynthesis of DHN melanin is synthesized by a polyketide pathway, through the genes encoding Polyketide synthase (PKS), Scytalone dehydratase (SCD), and 1,3,8-trihydroxynaphthalene reductase (THN). It started with a PKS using malonyl-CoA as a substrate to produce 1,3,6,8-tetrahydroxynaphthalene, 1,3,6,8-THN (Fujii et al., 2000), followed by reducatse catalysis to produce scytalone, dehydration by SCD to yield 1,3,8-trihydroxynaphthalene (1,3,8-THN), reduction by THN to yield vermelone, dehydration to produce melanin precursor 1,8-dihydroxynaphthalene (1,8-DHN), and then oxidation and polymerization to yield melanin.