HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Methoxy-3-methylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4-Acetyl-6-methoxy-1H-2-benzopyran-1,3(4H)-dione | HCID 57893130 | — |
| Product | 6-Methoxy-3-methylisoquinolin-1(2H)-one | HCID 12327060 | 74% |
Reaction Steps
Cyclic anhydride 42 (405 mg; 1.73 mmol) was dissolved in aqueous NH4OH and heated at reflux for 1.5 h. The mixture was cooled to RT and the solid was filtered then dried overnight to give 270 mg (74%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518874B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-346be20ffc7f4ac2a96728ff22d71394 |
| Source note | uspto-grants-2013_08 |