反应详情

NaBH4 (180 mg, 4.74 mmol) was added to a solution of 1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-one (2.56 g, 8.34 mmol) in methanol (15 ml) at 0° C., and stirred at room temperature for 1 hour. The reaction was quenched with H2O (50 ml) and extracted with ethyl acetate (20 ml×2). The combined organic phase was washed with H2O (20 ml×2) and brine (20 ml×2), dried over Na2SO4 and concentrated in vacuo to give 1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-ol (2.17 g, 84%) as a white solid: LCMS: 310 [M+1]+.

1. customThe reaction was quenched with H2O (50 ml)
2. extractionextracted with ethyl acetate (20 ml×2)
3. washThe combined organic phase was washed with H2O (20 ml×2) and brine (20 ml×2)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo