Diisopropylethylamine → HCID 59565074, compound

Participants

Reaction Steps

4-Trifluoromethoxyphenylsulfonyl chloride (4.34 g, 16.7 mmol) was added to a solution of 4-piperidone monohydrate hydrochloride (2.99 g, 19.5 mmol) and N,N-diisopropylethylamine (9.50 ml, 57.5 mmol) in CH2Cl2 (50 ml) at 0° C. and stirred at room temperature for 20 hours. The reaction mixture was concentrated in vacuo and the residue was diluted with ethyl acetate (250 ml), washed with aqueous 1 N HCl solution (50 ml), H2O (50 ml), saturated aqueous NaHCO3 solution (50 ml) and brine (50 ml), dried over Na2SO4 and concentrated in vacuo to give 1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-one (4.37 g, 81%) as a off-white solid.

Provenance & Evidence