Sodium borohydride → HCID 43394335, compound

Participants

Reaction Steps

NaBH4 (719 mg, 19.0 mmol) was added in portions to a suspension of 1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-one (3.07 g, 9.50 mmol) in ethanol (50 ml) at 0° C. and stirred at room temperature for 2 hours. The reaction was quenched with acetone (50 ml) at 0° C. and concentrated in vacuo. The residue was diluted with ethyl acetate (100 ml), washed with saturated aqueous NaHCO3 and brine, dried over Na2SO4, filtered and concentrated in vacuo to give 1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol (3.09 g, 100%) as a white solid: LCMS: 326 [M+1]+.

Provenance & Evidence