N-Hydroxyphthalimide → HCID 67118409, compound

Participants

Reaction Steps

Diethyl azodicarboxylate (8.86 g, 33.8 mmol) was added to a solution of 1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol (10.0 g, 30.7 mmol), 2-hydroxyisoindoline-1,3-dione (5.01 g, 30.7 mmol) and triphenylphosphine (8.86 g, 33.8 mmol) in tetrahydrofuran (100 ml) at 0° C. The reaction mixture was stirred at room temperature for 17 hours and concentrated in vacuo. The residue was purified by column chromatography (ethyl acetate/petroleum ether: 33/67) to give 2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione (11.6 g, 80%) as a white solid: LCMS: 471 [M+1]+.

Provenance & Evidence