反应详情

Hydrazine solution (138 mg, 2.75 mmol) was added to a solution of 2-(2-(4-fluorophenoxy)ethyl)isoindoline-1,3-dione (713 mg, 2.5 mmol) in methanol (8 ml) and stirred at room temperature for 4 hours. The resulting solid was filtered off and concentrated in vacuo. The residue was triturated with diethyl ether (30 ml), and the resulting solid was filtered off again and concentrated in vacuo to give 2-(4-fluorophenoxy)ethanamine (280 mg, 70%) as colorless oil: LCMS: 325 [M+1]+.

1. filtrationThe resulting solid was filtered off
2. concentrationconcentrated in vacuo
3. customThe residue was triturated with diethyl ether (30 ml)
4. filtrationthe resulting solid was filtered off again
5. concentrationconcentrated in vacuo