HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 59704735 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetic acid | HCID 6422 | 242.9% |
| Product | (S)-2-(pyrrolidin-3-yloxy)isoindoline-1,3-dione | HCID 67118875 | — |
Reaction Steps
Trifluoroacetic acid (3.42 g, 30 mmol) was added at 0° C. to a solution of (S)-tert-butyl 3-(1,3-dioxoisoin dolin-2-yloxy)pyrrolidin-1-carboxylate (3.32 g, 10 mmol) in CH2Cl2 (25 ml), and the whole was stirred at room temperature for 17 hours. The reaction was concentrated in vacuo and the residue was triturated with diethyl ether (100 ml) to give (S)-2-(pyrrolidin-3-yloxy)isoindoline-1,3-dione) trifluoroacetic acid salt (2.77 g, 80%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518934B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-63c34f0f09244c3287e5816e7615d725 |
| Source note | uspto-grants-2013_08 |