N-Hydroxyphthalimide → HCID 67118434, compound

Participants

Reaction Steps

Diethyl azodicarboxylate (1.23 ml, 2.70 mmol) was added dropwise to a solution of 1-(1-(4-(trifluoromethoxy)phenyl)cyclopropyl)piperidin-4-ol (750 mg, 2.45 mmol), 2-hydroxyisoindoline-1,3-dione (400 mg, 2.45 mmol) and triphenylphosphine (707 mg, 2.70 mmol) in tetrahydrofuran (15 ml) at 0° C. and the whole was stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography (ethyl acetate/hexane: 25/75 to 45/55) to give 2-(1-(1-(4-(trifluoromethoxy)phenyl)cyclopropyl)piperidin-4-yloxy)isoindoline-1,3-dione (1.00 g, 85%) as pale yellow amourphous.

Provenance & Evidence