1-Bromo-2-nitrobenzene → 2-Methyl-6-{3-[1-(2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl}pyridine

関与物質

反応手順

A well homogenised mixture of the Compound of Example 3 (20 mg, 0.09 mmol) and 1-bromo-2-nitrobenzene (22.8 mg, 0.11 mmol) was stirred at 90° C. for 0.5 h, then at 110° C. for 1 h. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether gradient from 3:7 to 4:6) affording the title product (8.3 mg).

情報源と証拠