Benzaldehyde → 2-[3-(1-Butylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	2-[3-(1-Benzylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine	HCID 87550713	—
Product	2-[3-(1-Butylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine	HCID 87550520	—

Reaction Steps

The title compound was prepared following the procedure described for the compound of Example 27, but substituting butyraldehyde for benzaldehyde. After the usual work-up procedure, the crude was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with a gradient Petroleum Ether-(EtOAc+1.4 N methanolic ammonia 1:0.1) from 90:10 to 30:70 affording the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08518916B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-2e3fe3762d6747e9bd75160e06d87cec
Source note	uspto-grants-2013_08